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February 18, 2021February 18, 2021

High Ferritin Levels Linked to Increased HLH Risk; Testing Urged

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People with high levels of the iron-storing protein ferritin may be at an increased risk for hemophagocytic lymphohistiocytosis (HLH), a new study suggests. Thus, they should undergo additional diagnostic tests ... Read more

January 14, 2021January 14, 2021

Liver Enzyme Ratio Tied to Higher Mortality Risk in Secondary HLH

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The proportions of two liver-associated enzymes found in adults with secondary hemophagocytic lymphohistiocytosis (sHLH) is an indicator of the patients’ mortality risk, a study suggests. These enzymes, called aspartate transaminase, ... Read more

January 7, 2021January 7, 2021

Consider Chronic Granulomatous Disease Diagnosis in Children With HLH

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Physicians should consider chronic granulomatous disease (CGD) in infants and children who present with hemophagocytic lymphohistiocytosis (HLH), as the latter can sometimes mask the former, according to a recent study. Recognizing ... Read more

December 17, 2020December 17, 2020

Fibrinogen May Be Survival Marker in Secondary HLH

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Low levels of the blood clotting factor fibrinogen in adults with secondary hemophagocytic lymphohistiocytosis (sHLH) are linked to an increased risk of mortality, a study suggested. That finding supports fibrinogen’s potential ... Read more

December 10, 2020December 10, 2020

‘Simple’ QuantiFERON‐TB Gold Blood Test May Help in Diagnosing HLH

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QuantiFERON-TB Gold by Quiagen, a widely used blood test, was found to be helpful in diagnosing hemophagocytic lymphohistiocytosis (HLH), a study reports. “This simple diagnostic test could really support pediatricians” ... Read more

December 3, 2020December 3, 2020

European CHMP Adopts Second Negative Opinion on Gamifant Authorization

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The European Committee for Medicinal Products for Human Use (CHMP) has recommended the denial of market authorization for Gamifant (emapalumab) for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in children ... Read more

November 12, 2020November 12, 2020

Tadekinig Alfa Moves Closer to US Market Launch With Manufacturing Deal

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Tadekinig alfa, AB2 Bio‘s investigational therapy for hemophagocytic lymphohistiocytosis (HLH), is one step closer to its U.S. market launch, thanks to a new manufacturing agreement between its developer and WuXi Biologics. AB2 Bio, ... Read more

October 15, 2020October 15, 2020

HSCT of Greater Benefit to Children with Confirmed Familial HLH, Trial Finds

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Overall five-year survival following hematopoietic stem cell transplant is higher among children with a confirmed diagnosis of familial hemophagocytic lymphohistiocytosis (HLH) than those lacking a confirmed diagnosis, a large clinical trial reported. ... Read more

October 1, 2020October 1, 2020

Mortality Risk in Pediatric HLH Linked in Study to Impaired Organ Function, Other Factors

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Hemophagocytic lymphohistiocytosis (HLH) pediatric patients at risk of short-term mortality share certain features, such as impaired blood clotting, abnormal liver function, and multiple organ dysfunction syndrome, or MODS, according to ... Read more

September 24, 2020September 24, 2020

Only 10.4% of Suspected HLH Cases Positive for Disease-causing Mutations, Study Finds

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Next-generation sequencing analysis for a panel of 15 genes identified disease-causing variants in only 10.4% of suspected cases of hemophagocytic lymphohistiocytosis (HLH), a new study reports. The results highlight the need ... Read more