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September 10, 2020September 10, 2020

Ruxolitinib Successfully Treats HLH in Boy With Viral Infection, Case Study Reports

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The anti-cancer medicine ruxolitinib was successfully used to treat a boy with hemophagocytic lymphohistiocytosis (HLH) who was unable to receive immunosuppressant therapies due to a viral infection, a case study ... Read more

August 6, 2020August 6, 2020

European CHMP Delivers Negative Opinion of Gamifant; Sobi Requests Re-examination

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The Committee for Medicinal Products for Human Use (CHMP) recommended denying Sobi‘s marketing authorization request for Gamifant (emapalumab) for the treatment of primary hemophagocytic lymphohistiocytosis (HLH) in children in Europe ... Read more

July 24, 2020July 24, 2020

High-dose Methylprednisolone Successfully Treats HLH, Case Report Shows

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A case of secondary hemophagocytic lymphohistiocytosis (HLH) — caused by pembrolizumab treatment for lung cancer — was successfully treated with high-dose methylprednisolone, according to a recent case report. The report, ... Read more

July 16, 2020July 16, 2020

Nivolumab Effective Against Epstein-Barr Virus-Associated HLH, Analysis Suggests

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The cancer medication nivolumab (marketed as Opdivo) can successfully treat patients with secondary hemophagocytic lymphohistiocytosis (HLH) triggered by Epstein-Barr virus (EBV) infection, a study shows. In the study, six of seven patients ... Read more

June 25, 2020June 26, 2020

Study: New Reduced-intensity Conditioning Regimen Before HSCT May Be Better to Treat HLH

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A new reduced-intensity conditioning (RIC) regimen based on targeted busulfan prior to allogeneic hematopoietic stem cell transplant (HSCT) may be an effective and safer approach to treat hemophagocytic lymphohistiocytosis (HLH), a multi-center ... Read more

June 18, 2020June 18, 2020

New Combo Treatment May Help Control Inflammation, Study Finds

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Certain interleukins — proteins that can boost inflammation — promote resistance to the corticosteroid dexamethasone (DEX), a first-line treatment for hemophagocytic lymphohistiocytosis (HLH), a study shows. These proteins activate a ... Read more

June 11, 2020June 11, 2020

Neurological Symptoms May Indicate HLH, Case Report Shows

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Unexplained neurological symptoms may be indicative of hemophagocytic lymphohistiocytosis, even in the absence of typical HLH symptoms such as fever, a new case report highlights. The report, “Neurological symptoms of ... Read more

June 4, 2020June 4, 2020

Rapid Diagnosis Crucial for Adults with HLH That Affects Brain

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The brain is rarely affected in adult-onset hemophagocytic lymphohistiocytosis (HLH), but its involvement is a serious complication and a quick diagnosis is critical to ensuring best possible outcomes for patients, a ... Read more

May 14, 2020May 14, 2020

Gamifant Combo Safe and Effective for Children with Primary HLH, Trial Confirms

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When used in combination with dexamethasone, Gamifant (emapalumab) safely controls inflammation in children with primary hemophagocytic lymphohistiocytosis (HLH), a Phase 2/3 trial showed. These findings were reported in the study, ... Read more

May 7, 2020May 7, 2020

Anakinra Infusions May Calm ‘Cytokine Storm’ in Adults With Macrophage Activation Syndrome, Small Study Suggests

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Continuous infusions of anakinra effectively halts the overactivation of immune and inflammatory responses in adults with a type of secondary hemophagocytic lymphohistiocytosis (HLH) called macrophage activation syndrome (MAS), according to a ... Read more