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January 30, 2020January 30, 2020

Despite Delay in HLH Diagnosis, Patient in Complete Remission After Chemotherapy for Lymphoma, Case Study Reports

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Despite a five-month delay in his hemophagocytic lymphohistiocytosis (HLH) diagnosis, a 63-year-old man with lymphoma achieved complete remission after six cycles of a brentuximab-based chemotherapy, a case study reports. The ... Read more

January 23, 2020January 23, 2020

Korean Woman Found to Have Rare Type of Lymphoma Associated With HLH

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A Korean woman was found to have a rare type of lymphoma associated with hemophagocytic lymphohistiocytosis (HLH), according to a case report. This type of cancer should be considered in ... Read more

January 16, 2020January 16, 2020

New Blood Markers Linked to HLH Prognosis in Children, Study Reports

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New blood markers have been linked to the prognosis of children younger than 14 with hemophagocytic lymphohistiocytosis (HLH), a study reports. The study, “Comparison between clinical features and prognosis of ... Read more

January 9, 2020January 9, 2020

Interferon-gamma Signaling Pathway is Overactive in Liver of Secondary HLH Patients, Study Says

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The overactivation in the liver of a signaling cascade involving interferon-gamma — a molecule that plays an important role in regulating the body’s immune and inflammatory responses — seems to ... Read more

December 12, 2019December 12, 2019

Dexamethasone-Ruxolitinib Combo Reduces Systemic Inflammation in Mouse Model of HLH, Study Shows

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The combination therapy of dexamethasone and ruxolitinib was more effective at reducing signs of systemic inflammation in a mouse model of hemophagocytic lymphohistiocytosis (HLH) than either medication alone, a preclinical study ... Read more

November 21, 2019November 21, 2019

‘Cytokine Storm Syndrome’ Hopes to Educate Doctors About HLH Symptoms and Care

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A book about hemophagocytic lymphohistiocytosis (HLH) — also known as cytokine release syndrome, macrophage activation syndrome — covers information ranging from disease symptoms and their clinical presentation to the most ... Read more

October 24, 2019November 14, 2019

Gamifant is Only Therapy Approved by FDA to Treat Primary Hemophagocytic Lymphohistiocytosis

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Gamifant (emapalumab-lzsg) is the first therapy approved by the U.S. Food and Drug Administration for children (including newborns) and adults with primary hemophagocytic lymphohistiocytosis (HLH), who have failed to respond ... Read more