Joana holds a BSc in Biology, a MSc in Evolutionary and Developmental Biology and a PhD in Biomedical Sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells — cells that made up the lining of blood vessels — found in the umbilical cord of newborns.
When used in combination with dexamethasone, Gamifant (emapalumab) safely controls inflammation in children with primary hemophagocytic lymphohistiocytosis (HLH), a Phase 2/3 trial showed. These findings were reported in the study, ... Read more
Germline variants — genetic mutations found in sperm or eggs that can be passed down to offspring — associated with hemophagocytic lymphohistiocytosis (HLH) are not more prevalent in patients with ... Read more
A highly cooperative multidisciplinary approach is crucial to improve the prognosis of adults with hemophagocytic lymphohistiocytosis (HLH), a study says. The study, “Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 ... Read more
The overactivation in the liver of a signaling cascade involving interferon-gamma — a molecule that plays an important role in regulating the body’s immune and inflammatory responses — seems to ... Read more
The combination therapy of dexamethasone and ruxolitinib was more effective at reducing signs of systemic inflammation in a mouse model of hemophagocytic lymphohistiocytosis (HLH) than either medication alone, a preclinical study ... Read more